Glucose One - 60 x Berberine 500mg Capsules

Steady energy depends on steady blood sugar. After 40, the metabolic systems that used to handle a normal meal start asking for more support. The post-meal slump becomes a daily feature instead of a rare event.

Berberine is one of the most studied compounds for supporting healthy glucose regulation and metabolic efficiency.

The metabolic side of aging

Insulin sensitivity declines with age. Glucose handling gets less efficient. The compounding effect is what you feel: the afternoon crash, the energy that doesn't match what you ate, the slow drift in metabolic flexibility.

Berberine activates AMPK — the cellular energy sensor that regulates how your body manages glucose, fat metabolism, and mitochondrial function. AMPK activation is one of the most studied targets in metabolic and longevity research.

How Glucose One works

Berberine supports healthy blood sugar regulation, metabolic flexibility, and sustained cellular energy. The published trials used 500mg, two to three times daily, taken with meals.

What's in each capsule

500mg of berberine HCL (≥97% purity). One capsule per serving. Hypromellose capsule, rice flour. No proprietary blends, no synthetic actives.

Who it's for

Adults 40+ who notice their energy dips after meals more than it used to. Anyone working on metabolic health alongside their longevity routine. People who track their blood sugar and want a research-supported tool for steadier numbers.

How to take it

One capsule with each main meal — typically two or three times daily. Take it at the start of the meal for best effect on the post-meal glucose response. Daily consistency matters more than precise timing.

What to expect

Most people notice steadier post-meal energy within one to two weeks. Glucose regulation improvements often show up on continuous glucose monitor data first. Sustained daily energy and metabolic flexibility build over months.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

• Activates AMPK — your master metabolic switch — the same pathway triggered by exercise and caloric restriction, supporting glucose uptake, fat oxidation, and energy balance
• Supports healthy blood sugar levels with effects on fasting glucose and HbA1c shown in clinical trials to be comparable to first-line pharmaceutical metabolic interventions
• Promotes healthy cholesterol and lipid balance by modulating lipid metabolism pathways, helping maintain cardiovascular health as part of a comprehensive wellness routine
• Improves gut microbiome composition by increasing populations of beneficial short-chain fatty acid-producing bacteria, supporting better digestion and reduced systemic inflammation
• Backed by over 4,500 published scientific studies making berberine one of the most extensively researched natural compounds for metabolic health available today
• Supports mitochondrial biogenesis through AMPK activation, helping your cells build new energy-producing mitochondria — a process that naturally slows down with age
• Sourced from a standardised extract and independently tested by third-party labs for purity, potency, and heavy metal content with every production batch

β-Nicotinamide Mononucleotide (NMN) (≥99% purity) 500mg per capsule. Serving: 2 capsules (1,000mg). Other Ingredients: Hypromellose (Capsule), Rice Flour.

What does Berberine do?

Berberine activates AMPK — often called the body's "master metabolic switch." It's the same pathway your body activates during exercise or caloric restriction. AMPK regulates how your body handles glucose, supports healthy fat metabolism, and supports mitochondrial biogenesis.

What does the research say?

A comprehensive meta-analysis of randomised controlled trials found that berberine significantly reduced fasting blood sugar, HbA1c, and triglycerides — with effects on glucose control comparable to metformin, one of the most widely studied metabolic compounds in longevity research. Liang et al., Journal of Ethnopharmacology, 2019 ↗

Research has also shown that berberine supports a healthier gut microbiome, increasing beneficial bacteria associated with better metabolic health and reduced systemic inflammation.

AMPK activation by berberine has been shown to support mitochondrial biogenesis and reduce markers of cellular ageing — placing it in the same mechanistic class as caloric restriction mimetics.

Why Glucose One?

With thousands of published studies, berberine is one of the most extensively researched natural compounds for metabolic health. Ours is sourced from a standardised extract and independently tested for purity and heavy metal content.