Sirtuin One - 60 x 98% Purity Trans-Resveratrol 500mg Capsules

Sirtuins are the proteins your cells use to handle stress, repair DNA, and run the longevity pathways researchers have been studying for two decades. They're also the proteins that activity drops on without the right inputs.

Trans-resveratrol is the most studied way to support them.

What sirtuins do

Sirtuins are a family of seven enzymes that regulate how your cells respond to stress — including the cellular stress that compounds with age. SIRT1, the most studied, supports mitochondrial function, metabolic regulation, and the DNA repair pathways your body relies on to keep cellular damage in check.

Sirtuin activity depends on NAD+. When NAD+ drops with age, sirtuins slow. Trans-resveratrol is one of the few compounds shown to directly activate SIRT1 — giving your cells the activation signal even as NAD+ levels decline.

Why trans-resveratrol specifically

Resveratrol exists in two forms — cis and trans. Only the trans form has meaningful bioactivity. Most products sold as "resveratrol" use a mixed form at 100–250mg. Ours is 98% pure trans-resveratrol at 500mg per capsule, dosed in line with the human trial literature.

How Sirtuin One works in the body

Trans-resveratrol activates the SIRT1 pathway, supporting cardiovascular function, mitochondrial biogenesis, and the body's natural antioxidant response. It also pairs synergistically with NMN — NMN supplies NAD+, trans-resveratrol activates the sirtuins that use it.

What's in each capsule

500mg of 98% pure trans-resveratrol. One capsule per serving. Hypromellose capsule, rice flour. No proprietary blends, no synthetic colors, no unnecessary additives.

Who it's for

Adults 40+ building a longevity routine. People who already take NMN and want to complete the foundational pairing. Anyone interested in supporting the cellular stress response pathways at the dose the research actually used.

How to take it

One capsule daily with a meal that contains some fat. Trans-resveratrol is fat-soluble — absorption is meaningfully better when taken with food. A handful of nuts, an avocado, or a meal containing healthy fats works well.

What to expect

Trans-resveratrol works at the cellular level over weeks, not days. Most people don't notice an immediate feeling. Over six to twelve weeks of consistent use, the support shows up as steadier energy, faster recovery, and the kind of resilience that's easier to feel than describe.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

• Activates SIRT1 longevity genes — the same cellular switches linked to caloric restriction, helping regulate inflammation, metabolism, and DNA repair
• Works synergistically with NMN by turning on the sirtuin proteins that depend on NAD+ as a co-factor, amplifying the benefits of both compounds
• Supports cardiovascular health through clinically demonstrated improvements in vascular function, cholesterol markers, and arterial elasticity
• Reduces systemic inflammation — a meta-analysis of 21 randomised controlled trials confirmed significant reductions in key inflammatory markers like CRP and TNF-α
• 98% pure trans-resveratrol sourced from Japanese knotweed — the biologically active form your body can actually use, unlike less effective cis-resveratrol
• Supports cognitive function by crossing the blood-brain barrier and activating neuroprotective pathways that help maintain memory and mental clarity with age
• Third-party tested for identity, potency, and contaminants with every batch, so you always know exactly what you are putting into your body

β-Nicotinamide Mononucleotide (NMN) (≥99% purity) 500mg per capsule. Serving: 2 capsules (1,000mg). Other Ingredients: Hypromellose (Capsule), Rice Flour.

What does Resveratrol do?

Trans-resveratrol activates SIRT1 — one of the most studied longevity genes. SIRT1 influences how your body handles inflammation, metabolism, DNA repair, and cellular stress. It's the same pathway your body activates during caloric restriction.

What does the research say?

A randomised controlled trial showed that resveratrol supplementation mimicked caloric restriction effects in obese adults — improving mitochondrial function, activating AMPK and SIRT1, and reducing markers of metabolic ageing. Timmers et al., Cell Metabolism, 2011 ↗

A meta-analysis of randomised controlled trials confirmed significant reductions in key inflammation markers — including CRP and TNF-α — with resveratrol supplementation. Koushki et al., Clinical Therapeutics, 2018 ↗

Research from Harvard Medical School showed that SIRT1 activation extended lifespan in multiple organisms and improved healthspan markers in mammals. Importantly, SIRT1 requires NAD+ to function — which is why resveratrol and NMN work so well together.

Why Sirtuin One?

We use 98% pure trans-resveratrol — the biologically active form. Each batch is independently tested for identity, potency, and purity.