Calm One - 60 x Apigenin 50mg Capsules

Sleep isn't just rest — it's when your body does its deepest repair work. During quality sleep, your brain clears metabolic waste, your cells regenerate, and your NAD+ levels are actively restored. Poor sleep accelerates biological ageing. Protecting it is one of the highest-leverage things you can do for longevity.

Calm One contains a targeted dose of apigenin — a natural flavonoid found in chamomile, parsley, and celery. Apigenin works through two mechanisms that matter for longevity. First, it binds to GABA receptors in the brain, promoting calm and supporting deeper sleep without grogginess. Second, it inhibits CD38 — the enzyme responsible for consuming up to 90% of your cellular NAD+ as you age.

That second mechanism is why Calm One pairs so well with Cell One. While NMN builds your NAD+ levels, apigenin helps protect them from being broken down overnight. It's a simple but powerful combination.

We use a high-purity apigenin extract, third-party tested for identity, potency, and contaminants. Take one capsule 30 to 60 minutes before bed. No melatonin dependency, no morning fog — just cleaner sleep and better NAD+ preservation while your body does what it does best: repair.

• Inhibits CD38 — the enzyme responsible for degrading up to 90% of your cellular NAD+ as you age, helping preserve the NAD+ your body needs for repair and energy
• Promotes deeper, more restorative sleep by naturally modulating GABA receptors in the brain, without the dependency risks or morning grogginess of pharmaceutical sedatives
• Protects your NAD+ levels overnight — the critical window when your body performs its deepest DNA repair, cellular maintenance, and metabolic recovery
• Pairs powerfully with Cell One — while NMN builds your NAD+ levels during the day, apigenin prevents CD38 from breaking them down while you sleep
• Supports healthy ageing through better sleep quality — research links poor sleep to accelerated epigenetic ageing, making sleep optimisation a high-leverage longevity strategy
• Derived from a high-purity apigenin extract with no melatonin, no artificial sedatives, and no habit-forming ingredients — just clean, research-backed sleep support
• Third-party tested for identity, potency, and contaminants, ensuring pharmaceutical-grade quality and full transparency with every batch we produce

Take 1 capsule daily with a meal. For best results, take alongside Cell One (NMN) as part of your morning protocol. Consistent daily use maintains sustained CD38 inhibition.

β-Nicotinamide Mononucleotide (NMN) (99% purity) 500mg per capsule. Serving: 2 capsules (1,000mg). Other Ingredients: Hypromellose (Capsule), Rice Flour.

What does Apigenin do?

Apigenin is a natural flavonoid that works in two important ways. First, it inhibits CD38 — an enzyme responsible for breaking down up to 90% of your cellular NAD+ as you age. By blocking CD38, apigenin helps preserve the NAD+ your body needs. Camacho-Pereira et al., Cell Metabolism, 2016 ↗

What does the research say?

Research demonstrated that CD38 expression increases substantially with age and is the primary driver of NAD+ decline. CD38 inhibition restored NAD+ levels in aged tissue and reversed mitochondrial decline. Chini et al., Nature Metabolism, 2020 ↗

Apigenin also supports healthy sleep by gently modulating GABA receptors in the brain — promoting relaxation without the dependency risks of pharmaceutical sleep aids.

This matters for longevity too: sleep quality is directly associated with biological ageing rate. Protecting both your NAD+ pool and your sleep quality in one ingredient is what makes apigenin uniquely valuable.

Why Calm One?

Apigenin is rare in that it supports both NAD+ preservation and sleep quality — two pillars of healthy ageing in a single ingredient. Our extract is high-purity and third-party tested.