Metabolic One Stack (NMN, Resveratrol, Berberine)
Cell One Plus + Glucose One
Support metabolism, blood sugar balance, and sustained energy with a stack built for healthier aging.
Key Benefits
- check_circle Supports healthy blood sugar and metabolism
- check_circle NMN & Resveratrol combined in one convenient capsule
- check_circle Two products instead of three — simplified daily routine
- check_circle Save vs buying each separately
- check_circle Third-party tested for purity
Introducing Metabolic One Stack (NMN, Resveratrol, Berberine)
Support metabolism, blood sugar balance, and sustained energy with a stack built for healthier aging.
What is Metabolic One Stack (NMN, Resveratrol, Berberine)?
Supports healthy blood sugar, energy balance, and metabolic function. Two products that help your metabolism work more efficiently as you age.
What's Inside
- Cell One Plus (NMN & Resveratrol) — Restores cellular energy and activates enzymes that help regulate glucose metabolism — in a single capsule
- Glucose One (Berberine) — Supports healthy blood sugar levels and metabolic efficiency
How It Works
Metabolic health is one of the strongest predictors of how well you age. This stack targets it from two angles: restoring NAD+ and activating sirtuin enzymes with our 2-in-1 formula, and supporting healthy blood sugar with Berberine — one of the most studied natural metabolic compounds available.
Key Benefits
- Combines NAD+ restoration with sirtuin activation in a single 2-in-1 capsule, paired with Berberine for comprehensive metabolic support
- Cell One Plus restores cellular energy while activating sirtuin enzymes that regulate glucose metabolism — all in one convenient formula
- Glucose One delivers research-grade Berberine to support healthy blood sugar levels and metabolic efficiency
- Every ingredient is third-party tested for purity exceeding 99%, manufactured under strict GMP conditions, and free from gluten, dairy, soy, and artificial additives
Directions
Take Cell One Plus with your morning meal alongside healthy fats. Take Glucose One with your largest meal of the day. All ingredients are pharmaceutical-grade and third-party tested.
Ingredients
Cell One Plus — NMN & Resveratrol
- NMN (Nicotinamide Mononucleotide) 250mg
- Trans-Resveratrol 250mg (Polygonum cuspidatum root extract, >98% purity)
- Other: Hypromellose (Capsule), Rice Flour
- Free from: gluten, dairy, soy, artificial colours, artificial preservatives
Glucose One — Berberine
- Berberine HCl 500mg (Berberis aristata root extract)
- Other: Hypromellose (Capsule), Rice Flour
- Free from: gluten, dairy, soy, artificial colours, artificial preservatives
Nutrition Information
Cell One Plus
| Amount Per Serving | % Daily Value |
|---|---|
| β-Nicotinamide Mononucleotide (NMN) (≥99% purity) 500 mg | † |
| Trans-Resveratrol (≥98% purity) 500 mg | † |
Glucose One
| Amount Per Serving | % Daily Value |
|---|---|
| Berberine HCl (≥97%) 1,000 mg | † |
The Science
Why these three together?
The Metabolic One Stack targets metabolic health through three distinct but connected pathways: AMPK activation, NAD+ restoration, and sirtuin signalling.
How each ingredient works
Berberine activates AMPK — your body's master metabolic sensor. A meta-analysis of randomised controlled trials found its effects on blood sugar and lipids comparable to metformin. Liang et al., Journal of Ethnopharmacology, 2019 ↗
NMN restores NAD+ levels — fuelling the metabolic enzymes that depend on this critical coenzyme for proper function. Yoshino et al., Science, 2021 ↗
Trans-Resveratrol activates SIRT1, which directly regulates insulin sensitivity, fat metabolism, and inflammatory responses. Timmers et al., Cell Metabolism, 2011 ↗
The synergy
These pathways talk to each other: AMPK activation increases NAD+ production. NAD+ powers sirtuin function. And SIRT1 activation enhances AMPK signalling — creating a positive feedback loop that supports metabolic health more effectively than targeting any single pathway alone.
45-Day Satisfaction Guarantee
At Vitra One, we believe our products should earn their place in your daily routine.
That's why every Vitra One product is backed by our 45-Day Satisfaction Guarantee.
We recommend taking your supplement consistently for at least 30 days as part of your routine. Individual experiences may vary. If you're not satisfied within 45 days of purchase, contact us and we'll provide a full refund.
No friction. No unnecessary questions.
This guarantee applies to purchases made through official Vitra One channels. Limit one refund per customer. Shipping fees are non-refundable.
Your Questions Answered
Everything you need to know about the Defence One Stack.
What's included in the Metabolic One Stack?
The Metabolic One Stack combines Cell One Plus (our 2-in-1 NMN & Resveratrol formula) with Glucose One (Berberine). This pairing targets both cellular energy production through NAD+ support and metabolic efficiency through AMPK activation — two complementary pathways that together provide comprehensive metabolic optimisation.
How does this stack support metabolic health?
NMN boosts NAD+ for mitochondrial energy production, Resveratrol activates sirtuins for cellular repair, and Berberine activates AMPK — your body's metabolic master switch. AMPK activation improves glucose uptake, supports insulin sensitivity, and promotes fat metabolism. Together, these pathways cover the full spectrum of metabolic health.
Is this stack suitable for people managing blood sugar?
Berberine has strong clinical evidence for supporting healthy blood sugar levels. However, if you are taking medication for blood sugar management (such as metformin or insulin), please consult your healthcare provider before starting this stack, as Berberine may enhance the effects of these medications.
When is the best time to take this stack?
Take Cell One Plus in the morning with breakfast for all-day NAD+ and sirtuin support. Take Glucose One (Berberine) with your largest meal of the day, or split across two meals, to align its glucose-moderating effects with your body's postprandial metabolic response.
How does this compare to the Longevity One Starter Stack?
The Longevity One Starter Stack focuses on foundational NAD+ support with NMN, Resveratrol, and Apigenin. The Metabolic One Stack replaces Calm One with Glucose One to specifically target metabolic health and blood sugar support. Choose based on your primary health goal — sleep and NAD+ preservation, or metabolic optimisation.
Customer Reviews
A Focused Stack That Delivers
"I wanted something more targeted than a five-product protocol but more complete than just NMN alone. Defence One hits exactly that spot. Three months in and my energy and recovery are both noticeably better."
Love The Build And Protect Concept
"The logic behind pairing Cell One Plus with Quercetin makes complete sense to me. You're building NAD+ and then giving your cells a defence layer at the same time. I've been on this for six weeks and feel sharper and less run-down post-workout."
Cleaner Recovery Since Starting This
"I exercise five days a week and was looking for antioxidant support that actually worked alongside my longevity routine. Defence One simplified everything. The soreness after hard sessions has reduced and I'm sleeping better too."
Transparent Formulas, Serious Purity
"What keeps me coming back is that both products in this stack are single-ingredient, properly dosed, and third-party tested. No proprietary blends, no filler. The quercetin is 98% pure and the Cell One Plus dose is exactly what the research recommends."
Good Stack, Takes A Few Weeks
"Give it four to six weeks before you judge it. I didn't notice much in the first two weeks but by week five the difference in my afternoon energy and post-gym recovery was clear. Taking off one star only because the quercetin capsules are a little large."
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