Autophagy One - 60 x Spermidine 5mg Capsules

Autophagy is your body's cellular housekeeping system. It identifies damaged proteins, broken organelles, and accumulated waste inside your cells — then breaks them down and recycles the components into fresh building materials. It's one of the most important longevity mechanisms we know of, and it naturally declines with age.

Autophagy One delivers a clinically relevant dose of spermidine — a naturally occurring polyamine found in wheat germ, aged cheese, and fermented foods. Spermidine is one of the few compounds shown to directly induce autophagy in human cells, and research has linked higher spermidine intake to improved cardiovascular health and longevity markers.

We source our spermidine from a standardised wheat germ extract, carefully processed to deliver a consistent and verified dose in every capsule. Each batch undergoes third-party testing for purity, potency, and contaminants.

Most longevity researchers consider autophagy activation a cornerstone of any serious anti-ageing protocol. Take one capsule daily with your morning meal. For deeper cellular renewal, pair Autophagy One with Cell One and Mito One — together they target three distinct but complementary pathways: energy production, mitochondrial quality, and cellular cleanup.

• Activates autophagy — your cells' natural recycling system that clears damaged proteins, broken organelles, and accumulated waste to keep cells functioning at their best
• Linked to longer lifespan in a 20-year prospective study published in the American Journal of Clinical Nutrition, where higher spermidine intake was associated with significantly lower all-cause mortality
• Supports cardiovascular health by promoting the cellular cleanup processes that help maintain healthy heart tissue, blood vessels, and arterial function over time
• Enhances cognitive function — a randomised controlled trial showed improved memory performance in older adults with subjective cognitive decline after spermidine supplementation
• One of the few compounds shown to extend lifespan across multiple species including yeast, flies, worms, and mice, demonstrating remarkably consistent longevity effects
• Derived from a standardised wheat germ extract, carefully processed to deliver a reliable and verified dose of spermidine in every capsule you take
• Independently tested for purity, potency, and contaminants with every batch — because when it comes to your health, transparency and quality are non-negotiable

Take 1 capsule daily with a meal. Works synergistically with fasting practices. For cellular renewal protocols, pair with Mito One (Urolithin A) and Cell One.

β-Nicotinamide Mononucleotide (NMN) (99% purity) 500mg per capsule. Serving: 2 capsules (1,000mg). Other Ingredients: Hypromellose (Capsule), Rice Flour.

What is Spermidine?

Spermidine activates autophagy — your body's built-in recycling system that clears out damaged proteins and cellular debris. The importance of autophagy was recognised with the 2016 Nobel Prize in Physiology or Medicine, awarded to Yoshinori Ohsumi for his discoveries in this field.

What does the research say?

A 20-year prospective study found that people with higher dietary spermidine intake had significantly lower rates of all-cause mortality — including cardiovascular and cancer-related deaths. Kiechl et al., American Journal of Clinical Nutrition, 2018 ↗

Spermidine is one of the few compounds shown to extend lifespan and provide cardioprotection consistently across multiple species — from yeast and flies to mice. Eisenberg et al., Nature Medicine, 2016 ↗

A randomised controlled trial showed that spermidine supplementation improved memory performance in older adults experiencing age-related cognitive decline. Wirth et al., Cortex, 2018 ↗

Why Autophagy One?

Impaired autophagy is one of the nine hallmarks of ageing. López-Otín et al., Cell, 2013 ↗ Our spermidine is derived from a standardised wheat germ extract, independently tested for potency and purity with every batch.