Calm One - 60 x Apigenin 50mg Capsules

You used to fall asleep when your head hit the pillow. Recovery happened on its own. Stress rolled off without leaving a residue. Then somewhere after 40, the quality of your downtime started to shift.

Apigenin is a flavonoid found naturally in chamomile, parsley, and celery — and one of the most studied compounds for supporting the body's calming, restorative pathways.

Why your recovery side matters

The longevity conversation usually focuses on energy and output. The other side — the calming, restorative biology that lets you actually recover overnight — is just as important. Sleep quality, stress resilience, and overnight cellular repair all rely on it.

Apigenin supports the GABA pathway and binds to receptors involved in the body's natural calm response. It also supports NAD+ preservation overnight by gently moderating CD38 activity — a small but useful piece of the longevity puzzle.

How Calm One works

50mg of pure apigenin per capsule. Supports the body's calming pathways without the heaviness of a sleep aid. Most people use it in the evening to wind down — the kind of support that helps you settle without slowing you down.

What's in each capsule

50mg of apigenin (≥98% purity). One capsule per serving. Hypromellose capsule, rice flour. No proprietary blends, no melatonin, no synthetic sleep aids.

Who it's for

Adults 40+ who notice their evenings don't wind down the way they used to. People with stress that lingers past bedtime. Anyone whose longevity routine has the daytime energy side covered and wants to support overnight recovery too.

How to take it

One capsule in the evening, roughly 30 to 60 minutes before sleep. Take with a small amount of fat — apigenin is fat-soluble. Daily use is where the compounding shows.

What to expect

Most people notice steadier evenings and easier sleep onset within the first week. Sleep quality improvements typically deepen over weeks two through six. Apigenin is not a sedative — it supports the body's natural calming pathways rather than overriding them.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

• Inhibits CD38 — the enzyme responsible for degrading up to 90% of your cellular NAD+ as you age, helping preserve the NAD+ your body needs for repair and energy
• Promotes deeper, more restorative sleep by naturally modulating GABA receptors in the brain, without the dependency risks or morning grogginess of pharmaceutical sedatives
• Protects your NAD+ levels overnight — the critical window when your body performs its deepest DNA repair, cellular maintenance, and metabolic recovery
• Pairs powerfully with Cell One — while NMN builds your NAD+ levels during the day, apigenin prevents CD38 from breaking them down while you sleep
• Supports healthy ageing through better sleep quality — research links poor sleep to accelerated epigenetic ageing, making sleep optimisation a high-leverage longevity strategy
• Derived from a high-purity apigenin extract with no melatonin, no artificial sedatives, and no habit-forming ingredients — just clean, research-backed sleep support
• Third-party tested for identity, potency, and contaminants, ensuring pharmaceutical-grade quality and full transparency with every batch we produce

β-Nicotinamide Mononucleotide (NMN) (≥99% purity) 500mg per capsule. Serving: 2 capsules (1,000mg). Other Ingredients: Hypromellose (Capsule), Rice Flour.

What does Apigenin do?

Apigenin is a natural flavonoid that works in two important ways. First, it inhibits CD38 — an enzyme responsible for breaking down up to 90% of your cellular NAD+ as you age. By blocking CD38, apigenin helps preserve the NAD+ your body needs. Camacho-Pereira et al., Cell Metabolism, 2016 ↗

What does the research say?

Research demonstrated that CD38 expression increases substantially with age and is the primary driver of NAD+ decline. CD38 inhibition restored NAD+ levels in aged tissue and reversed mitochondrial decline. Chini et al., Nature Metabolism, 2020 ↗

Apigenin also supports healthy sleep by gently modulating GABA receptors in the brain — promoting relaxation without the dependency risks of pharmaceutical sleep aids.

This matters for longevity too: sleep quality is directly associated with biological ageing rate. Protecting both your NAD+ pool and your sleep quality in one ingredient is what makes apigenin uniquely valuable.

Why Calm One?

Apigenin is rare in that it supports both NAD+ preservation and sleep quality — two pillars of healthy ageing in a single ingredient. Our extract is high-purity and third-party tested.