Metabolic One Stack (NMN, Trans-Resveratrol & Berberine)
Cell One Plus + Glucose One
Support metabolism, blood sugar balance, and sustained energy with a stack built for healthier aging.
Key Benefits
- check_circle Supports healthy blood sugar and metabolism
- check_circle NMN & Resveratrol combined in one convenient capsule
- check_circle Two products instead of three — simplified daily routine
- check_circle Save vs buying each separately
- check_circle Third-party tested for purity
Introducing Metabolic One Stack (NMN, Trans-Resveratrol & Berberine)
Support metabolism, blood sugar balance, and sustained energy with a stack built for healthier aging.
Dietary Supplement Description
Steady energy depends on steady metabolism. After 40, the systems your body uses to handle glucose and produce cellular energy start asking for more support. The afternoon slump, the post-meal crash, the energy that doesn't match what you ate — that's the metabolic side of aging, and it has a biology.
The Metabolic One Stack pairs the foundational NAD+ duo (NMN + trans-resveratrol) with berberine — the most studied compound for metabolic flexibility and healthy glucose regulation.
What's happening underneath
Insulin sensitivity declines with age. Glucose handling gets less efficient. NAD+ — the coenzyme behind energy production — drops by roughly half between your twenties and your fifties. The three biologies are connected: when one slows, the others feel it.
Berberine activates AMPK, the cellular energy sensor that regulates glucose metabolism and mitochondrial function. NMN supports NAD+ levels. Trans-resveratrol activates the sirtuin pathway that uses NAD+. Together, the stack covers cellular energy supply, sirtuin activation, and metabolic regulation at once.
What's in the stack
Cell One: 500mg NMN (≥99% purity) per daily capsule.
Sirtuin One: 500mg trans-resveratrol (98% pure) per daily capsule.
Glucose One: 500mg berberine HCL (≥97% purity), taken with meals.
Who it's for
Adults 40+ who notice their metabolism doesn't run the way it used to. People tracking blood sugar who want research-supported support alongside diet and training. Anyone building a longevity routine and choosing to add metabolic regulation to the foundation.
How to take it
Cell One and Sirtuin One with your morning meal. Glucose One with each main meal — typically two or three doses across the day. Berberine works best taken at the start of the meal. Daily consistency over weeks is where the compounding lives.
What to expect
Cell One Plus and Sirtuin One show up first — steadier daytime energy and sharper afternoon focus within two to four weeks. Glucose One's effect on post-meal energy often shows up within the first one to two weeks, particularly if you track with a CGM. Sustained metabolic flexibility builds over months.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Key Benefits
- Combines NAD+ restoration with sirtuin activation in a single 2-in-1 capsule, paired with Berberine for comprehensive metabolic support
- Cell One Plus restores cellular energy while activating sirtuin enzymes that regulate glucose metabolism — all in one convenient formula
- Glucose One delivers research-grade Berberine to support healthy blood sugar levels and metabolic efficiency
- Every ingredient is third-party tested for purity exceeding 99%, manufactured under strict GMP conditions, and free from gluten, dairy, soy, and artificial additives
Directions
Follow the individual dosing instructions for each product included in this stack. Take with a meal containing healthy fats for optimal absorption. Consistent daily use is important for sustained results.
Ingredients
Cell One Plus — NMN & Resveratrol
- NMN (Nicotinamide Mononucleotide) 250mg
- Trans-Resveratrol 250mg (Polygonum cuspidatum root extract, >98% purity)
- Other: Hypromellose (Capsule), Rice Flour
- Free from: gluten, dairy, soy, artificial colours, artificial preservatives
Glucose One — Berberine
- Berberine HCl 500mg (Berberis aristata root extract)
- Other: Hypromellose (Capsule), Rice Flour
- Free from: gluten, dairy, soy, artificial colours, artificial preservatives
Nutrition Information
Cell One Plus
| Amount Per Serving | % Daily Value |
|---|---|
| β-Nicotinamide Mononucleotide (NMN) (≥99% purity) 500 mg | † |
| Trans-Resveratrol (≥98% purity) 500 mg | † |
Glucose One
| Amount Per Serving | % Daily Value |
|---|---|
| Berberine HCl (≥97%) 1,000 mg | † |
The Science
Why these three together?
The Metabolic One Stack targets metabolic health through three distinct but connected pathways: AMPK activation, NAD+ restoration, and sirtuin signalling.
How each ingredient works
Berberine activates AMPK — your body's master metabolic sensor. A meta-analysis of randomised controlled trials found its effects on blood sugar and lipids comparable to metformin. Liang et al., Journal of Ethnopharmacology, 2019 ↗
NMN restores NAD+ levels — fuelling the metabolic enzymes that depend on this critical coenzyme for proper function. Yoshino et al., Science, 2021 ↗
Trans-Resveratrol activates SIRT1, which directly regulates insulin sensitivity, fat metabolism, and inflammatory responses. Timmers et al., Cell Metabolism, 2011 ↗
The synergy
These pathways talk to each other: AMPK activation increases NAD+ production. NAD+ powers sirtuin function. And SIRT1 activation enhances AMPK signalling — creating a positive feedback loop that supports metabolic health more effectively than targeting any single pathway alone.
90 days. Full refund. No friction.
At Vitra One, our products should earn their place in your daily routine.
That's why every Vitra One product is backed by a 90-day return policy.
Take it consistently for at least 30 days as part of your routine. Individual experiences vary. If you're not satisfied within 90 days of purchase, contact us — full refund.
No friction. No unnecessary questions.
This policy applies to purchases made through official Vitra One channels. One refund per customer. Shipping fees are non-refundable.
Your Questions Answered
Can I take NMN & Resveratrol and Berberine together?
Yes. NMN & Resveratrol and Berberine are commonly stacked and have complementary mechanisms — that's exactly why we paired them in this stack. Take them together with a meal containing healthy fats for optimal absorption.
How is this different from just taking Cell One Plus?
When should I take each component?
Will berberine cause stomach upset?
Can I take this with diabetes medication?
Is the bundle better value than buying separately?
Customer Reviews
The Metabolic Layer I Was Missing
"I'd been on NMN and resveratrol for a year. Adding berberine through this stack flattened my post-meal energy curve in the first two weeks. CGM data backs it up."
Coordinated System
"Three products, three pathways, one bundle. Cheaper than buying separately and the doses match the trials."
Steady Energy All Day
"Afternoon slump is gone. Post-meal crashes are smaller. Three weeks in."
Solid Stack — Berberine Takes Getting Used To
"First three days the berberine gave me mild stomach discomfort. Once I started taking it at the start of the meal as directed, no issues. Working well."
Pairs With My Training
"I train fasted in the morning. The stack supports the rest of the day. Sustained energy without crashes."
Doctor-Approved
"Shared the ingredient list with my physician before starting. She had no concerns. Two months in, my fasting glucose is the best it's been in five years."
Real Doses
"500mg NMN, 500mg trans-resveratrol, 500mg berberine. All match the published trials. Most stacks undershoot."
Quiet, Compounding Effect
"Not flashy. Just consistent. Six weeks in, my baseline has steadily moved up."
Three Bottles, Three Daily Doses
"Logistics take getting used to — berberine with meals adds a step. Worth it for the metabolic support."
Best Metabolic Stack I've Tried
"Tried building this myself from three other brands. The coordination here is better, the doses are higher, and the value is better."
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