Renewal One Stack (NMN, Trans-Resveratrol & Spermidine)

What ships in the Renewal One Stack

Two bottles. The 2-in-1 NAD+ and sirtuin foundation paired with the cellular cleanup layer:

• Cell One Plus — 30 capsules, each combining 500mg of pharmaceutical-grade NMN (≥99% purity) with 500mg of trans-resveratrol (>98% pure trans-isomer). One daily 2-in-1 capsule.
• Autophagy One — 30 capsules of 1mg spermidine, derived from premium wheat germ extract and standardised for consistent potency.

All third-party tested batch by batch. Vegetarian HPMC capsules. No proprietary blends, no synthetic additives. Bundle pricing saves $49 versus buying the two bottles separately, and subscription stacks another 20% off every refill.

The quiet cleanup your cells stopped doing on their own

Every cell in your body runs a cleanup process: damaged proteins get tagged, worn-out structures get recycled, the machinery refreshes itself. That process is called autophagy — and it slows with age. NAD+ slows too, which is why the energy and recovery your body managed effortlessly in your 30s starts asking for more. The Renewal One Stack works both pathways at once. Cell One Plus restores the NAD+ that drives cellular energy and sirtuin signalling. Autophagy One activates the gene pathway (BECN1, ATG family) that triggers autophagy — the same pathway the 2016 Nobel Prize in Physiology was awarded for.

The wins that build week over week

• Supports cellular cleanup, so the clutter that compounds into aging gets cleared
• Helps maintain NAD+ levels, so cellular energy production stays on
• Activates sirtuins, so the longevity pathway your cells use stays online
• Backs cognitive function long-term, so the brain stays sharp
• A simple two-bottle daily routine that compounds over months

How to settle into the routine

Order the Renewal One Stack on this page. Subscribe to save 20% on every refill across both bottles — pause, skip, or cancel anytime. Morning: Cell One Plus with breakfast, ideally a meal with some fat (eggs, nuts, avocado) so the trans-resveratrol absorbs properly. Evening: Autophagy One with dinner or before bed — autophagy peaks during your body's natural overnight repair cycle. Cell One Plus typically shows up first — steadier energy and sharper focus within two to four weeks. Autophagy One is quieter; you'll feel it as cellular resilience that's easier to notice three months in than three days in. Stay consistent — the compounding is the entire point.

• Supports NAD+ supply, sirtuin activation, and autophagy in one routine
• Combines a 2-in-1 foundation with the cellular cleanup layer
• Built for long-game cellular resilience that compounds over months
• Saves versus buying the two bottles individually

This stack contains two separate bottles, each with its own supplement facts:

• Cell One Plus: NMN (Nicotinamide Mononucleotide) 500mg + Trans-Resveratrol 500mg per single 2-in-1 capsule, microcrystalline cellulose, vegetarian HPMC capsule. 30 capsules.
• Autophagy One: Spermidine 1mg (from wheat germ extract), microcrystalline cellulose, vegetarian HPMC capsule. 30 capsules. Contains wheat.

Free from dairy, soy, artificial colours, and artificial preservatives. All third-party tested.

Each compound in the Renewal One Stack is backed by published human research:

• NMN: Clinical trials at 250-1200mg/day demonstrate NAD+ restoration through the salvage pathway. Cell One Plus delivers 500mg per daily 2-in-1 capsule.
• Trans-Resveratrol: SIRT1 activating compound (STAC) research established the >98% trans-isomer as the bioactive form. Cell One Plus combines 500mg trans-resveratrol with NMN in one capsule for the foundational longevity pairing.
• Spermidine: Activates autophagy through the BECN1 and ATG gene family. The 2016 Nobel Prize in Physiology was awarded for autophagy research. A prospective cohort study published in the American Journal of Clinical Nutrition linked higher dietary spermidine intake to lower all-cause mortality over a 20-year follow-up.

The combination targets cellular energy supply and the cleanup pathway in parallel — building and clearing simultaneously, which is how cells stay functional across decades.